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                              May 16, 2022

       Jeffrey S. Hackman
       President and Chief Executive Officer
       Comera Life Sciences Holdings, Inc.
       12 Gill Street
       Suite 4650
       Woburn, Massachusetts 01801

                                                        Re: Comera Life
Sciences Holdings, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed May 5, 2022
                                                            File No. 333-264686

       Dear Mr. Hackman:

              We have limited our review of your registration statement to
those issues we have
       addressed in our comments. In some of our comments, we may ask you to
provide us with
       information so we may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Registration Statement on Form S-1

       Cover Page

   1.                                                   We note the significant
number of redemptions of OTR Acquisition Corp.'s Class A
                                                        common stock in
connection with your business combination and that the shares being
                                                        registered for resale
will constitute a considerable percentage of your public float. We also
                                                        note that all of the
shares being registered for resale were purchased by the selling
                                                        securityholders for
prices considerably below the current market price of OTR Acquisition
                                                        Corp.'s Class A common
stock. Highlight the significant negative impact sales of shares
                                                        on this registration
statement could have on the public trading price of the Class A
                                                        common stock following
your business combination.
 Jeffrey S. Hackman
FirstName   LastNameJeffrey S. Hackman
Comera Life   Sciences Holdings, Inc.
Comapany
May         NameComera Life Sciences Holdings, Inc.
      16, 2022
May 16,
Page  2 2022 Page 2
FirstName LastName
2.       Please revise here and throughout to update your disclosures
throughout the filing and
         address areas that appear to need updating or that present
inconsistencies. Non-exclusive
         examples of areas where disclosure should be updated are as follows:

                Disclose whether the Business Combination has been completed.
To the extent the
              Business Combination has been consummated, please tell us why it
is material to
              investors to present a discussion of the mechanics of the
Business Combination in the
              Prospectus Summary.
                Your disclosure on page 108 indicates that the results of one
of your clinical studies
              are "expected to be available by February 2022."
                Your disclosure on page 133 indicates that you expect to pay an
annual basis to
              certain of your named executive officers in the first quarter of
calendar year 2022.
                Your Principal Stockholders table should show beneficial
ownership following the
              Business Combination.
Management's Discussion and Analysis of Financial Condition and Results of
Operations, page
93

3.       In light of the significant number of redemptions and the possibility
that the company will
         not receive significant proceeds from exercises of the warrants,
expand your discussion of
         capital resources to address any changes in the company   s liquidity
position since the
         business combination. If the company is likely to have to seek
additional capital, discuss
         the effect of this offering on the company   s ability to raise
additional capital.

4.       Please expand your discussion on page 94 regarding the impact of sales
of common stock
         made pursuant to the registration statement on the price of your
common stock to
         highlight the fact that, based on the disclosure in the Principal
Stockholders table and data
         regarding redemptions of OTR Acquisition Corp.'s Class A common stock,
four beneficial
         owners whose aggregate ownership totals approximately 95% of your
outstanding shares,
         will be able to sell all of their shares for so long as the
registration statement of which this
         prospectus forms a part is available for use.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Alan Campbell at 202-551-4224 or Celeste Murphy at
202-551-3257 with
any questions.
 Jeffrey S. Hackman
Comera Life Sciences Holdings, Inc.
May 16, 2022
Page 3

                                                   Sincerely,
FirstName LastNameJeffrey S. Hackman
                                                   Division of Corporation
Finance
Comapany NameComera Life Sciences Holdings, Inc.
                                                   Office of Life Sciences
May 16, 2022 Page 3
cc:       Janeane Ferrari, Esq.
FirstName LastName