Comera Life Sciences Holdings, Inc.
12 Gill Street
Suite 4650
Woburn, Massachusetts 01801
Tel: (617) 871-2101
April 13, 2022
VIA EDGAR
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
Attention: Alan Campbell and Celeste Murphy
| Re: | Comera Life Sciences Holdings, Inc. |
| Registration Statement on Form S-4 |
| File No. 333-263377 |
Dear Mr. Campbell and Ms. Murphy
Pursuant to Rule 461 under the Securities Act of 1933, as amended, the registrant, Comera Life Sciences Holdings, Inc. hereby requests acceleration of effectiveness of the above-referenced Registration Statement so that it will become effective at 9:00 a.m. ET on Thursday, April 14, 2022, or as soon as practicable thereafter.
Very truly yours,
COMERA LIFE SCIENCES HOLDINGS, INC.
/s/ Jeffrey S. Hackman
Jeffrey S. Hackman
Chief Executive Officer
| cc: | Loeb & Loeb LLP |
| • | Mitchell S. Nussbaum, Esq. |
| • | Janeane R. Ferrari, Esq. |